Personal tools
Document Actions

2012-D-003-SUP - Abstract

Grant Information

Diabetes - Start-Up
The Role of Circadian Clock in Regulation of Beta-cell Survival and Function in Diabetes
Aleksey Matveyenko, PhD
Endocrinology and Diabetes
Funding Status
  • Withdrawn
  • 3 years, $70,000 per year
  • 7/1/2012 to 6/30/2015


2012-D-003-SUP - Abstract
Brief Summary
"The Role of Circadian Clock in Regulation of Beta-Cell Survival and Function in Diabetes"

Millions of Americans are exposed to shift work and many other environmental conditions that disrupt normal circadian rhythms. Environmental conditions associated with disrupted circadian rhythms greatly increase the risk for development of Type 2 diabetes and also significantly hinder the treatment and management of hyperglycemia in existing patients with diabetes.

The goal of the current proposal is to investigate molecular mechanisms responsible for increased risk for diabetes in people experiencing daily disruptions in circadian rhythms. Thus research objectives of the grant will be to:

1) Characterize pancreatic beta-cell genes that are under circadian control

2) Demonstrate how expression of these genes is altered following exposure to environmental conditions associated with circadian disorders

3) Identify molecular pathways in beta-cells that are disturbed in response to circadian disorders and why this makes pancreatic beta-cells more vulnerable to death and dysfunction and consequent predisposition to diabetes.

online help

You are currently browsing the grant area of the website, where you have access to abstracts from research projects funded by LLHF.

The Funded Research area has a complete list of active and completed grants.


Powered by Plone CMS, the Open Source Content Management System

This site conforms to the following standards: