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2012-D-003-SUP - Abstract

Grant Information

Grant
2012-D-003-SUP
Diabetes - Start-Up
Title
The Role of Circadian Clock in Regulation of Beta-cell Survival and Function in Diabetes
Investigator
Aleksey Matveyenko, PhD
Institution
UCLA
Endocrinology and Diabetes
Funding Status
  • Withdrawn
  • 3 years, $70,000 per year
  • 7/1/2012 to 6/30/2015

Abstract

2012-D-003-SUP - Abstract
Brief Summary
"The Role of Circadian Clock in Regulation of Beta-Cell Survival and Function in Diabetes"

Millions of Americans are exposed to shift work and many other environmental conditions that disrupt normal circadian rhythms. Environmental conditions associated with disrupted circadian rhythms greatly increase the risk for development of Type 2 diabetes and also significantly hinder the treatment and management of hyperglycemia in existing patients with diabetes.

The goal of the current proposal is to investigate molecular mechanisms responsible for increased risk for diabetes in people experiencing daily disruptions in circadian rhythms. Thus research objectives of the grant will be to:

1) Characterize pancreatic beta-cell genes that are under circadian control

2) Demonstrate how expression of these genes is altered following exposure to environmental conditions associated with circadian disorders

3) Identify molecular pathways in beta-cells that are disturbed in response to circadian disorders and why this makes pancreatic beta-cells more vulnerable to death and dysfunction and consequent predisposition to diabetes.


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