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2007-A-027-FEL - Abstract

Grant Information

Grant
2007-A-027-FEL
Aging - Fellowship
Title
A Mechanistic Study of Infectious Proteins
Investigator
John Price, PhD
Institution
UCSF
Institute for Neurodegenerative Disease
Funding Status
  • Completed
  • 3 years, $60,000 per year
  • 7/1/2007 to 6/30/2010

Abstract

2007-A-027-FEL - Abstract
Brief Summary
"A Mechanistic Study of Infectious Proteins" Multiple neurodegenerative diseases are caused by the accumulation of protein in the brain. Two of these disorders, Alzheimer's and prion diseases form protein aggregates that can be infectious. The protein aggregates are mainly composed of a single protein, either A-beta (Alzheimer’s) or PrP (prion diseases). These proteins are both expressed naturally in healthy people throughout their lives, but the misfolding of either protein causes aggregation and death of brain tissue. Understanding this misfolding mechanism is very important because experimental results suggest that it is not simple, random, aggregation. It seems to occur in an ordered process that effects the host in a remarkably specific manner. The overall goal of my research is to develop a mechanistic model for the propagation of misfolded protein within the Alzheimer’s and prion diseases. Understanding this process is key to stopping the progression of the disease, and also understanding how the fidelity of strains is maintained without DNA and/or RNA. I am using the prions of mice and hamsters as my model and focusing on two specific objectives. 1) Establishing the minimum number of components necessary for the production of infectious proteins in a cell-free environment, and 2) Investigate the mechanism of the prion propagation in vitro.

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