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2001/1PP - Abstract

Grant Information

Grant
2001/1PP
Diabetes - Fellowship
Title
T-cadherin in the Pancreas: Role in Islet Development, Regeneration and the Pathogenesis of Type 2 Diabetes
Investigator
Bjorn Tyrberg, Dr Med Sc
Institution
UCSD
Cancer Center at Burnham Institute
Funding Status
  • Completed
  • 3 years, $53,000 per year
  • 7/1/2001 to 6/30/2004

Abstract

2001/1PP - Abstract
Brief Summary
"T-cadherin in the Pancreas: Role in Islet Development, Regeneration and the Pathogenesis of Type 2 Diabetes"

Diabetes, particularly Type 2, is epidemic throughout the world. It is clear that failure of the pancreatic insulin-producing cells, i.e. the ß-cells play a critical role in the development of diabetes. Revealing the molecular mechanisms underlying ß-cell function may provide insight into the reasons for ß-cell failure in diabetes.

These studies seek to explain the role of a particular protein, T-cadherin, in ß-cells. When the T-cadherin gene is eliminated in mice, they develop diabetes at age 3 to 5 months. The explanation of this phenomenon is not yet clear, but experimental evidence points toward a malfunction of ß-cell insulin secretion. Moreover, T-cadherin has an atypical distribution within the ß-cells of normal mice. Usually, cadherins are found on the surface of cells and are involved in cell-to-cell interactions. In ß-cells, T-cadherin is instead found in the cytoplasm in a fashion that resembles the distribution of insulin granules. If this can be established, it is reasonable to postulate that T-cadherin is directly involved in the process of insulin secretion, and is a possible explanation for the altered insulin secretion and presence of diabetes in these mice.

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