Funded Research
Up one levelAs of December 31, 2010, the LLHF has awarded approximately $90 million in grants, out of which approximately 130 medical research grants were awarded to major universities and institutions in State of California. Access the links below for a brief summary of the projects submitted by our outstanding research scientists in both the Aging and Diabetes funding categories.
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Fellowship - Stanford University - Qing Li, MD, PhD - The Role of Plasmacytoid Dendritic Cells in Type 1 Diabetes Mellitus |
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Fellowship - UCLA - Safia Costes, PhD - Role of Proteosomal Ubiquitin Pathway in Endoplasmic Reticulum Stress in Beta Cells |
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Fellowship - Stanford University - Jonghyeob Lee, PhD - Purification and Expansion of Candidate Human Pancreatic Progenitor Cells |
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Fellowship - UCSF - Hani Jouihan, PhD - Regulation of Insulin Sensitivity by Macrophage-Specific PGC-1beta |
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Network - UCSF - Ajay Chawla, MD, PhD - The Larry L. Hillblom Center for the Immunobiology of Type 2 Diabetes |
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Fellowship - The Palo Alto Institute - Kurt Lucin, PhD - The Effect of Beclin 1 on Neurodegeneration in Alzheimer's Disease and Aging |
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Fellowship - Stanford University - Dror Sagi, PhD - An Engineering Approach to Increase Lifespan |
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Fellowship - Stanford University - Rachel Nosheny, PhD - Cholinergic terminal structure and function in Down syndrome |
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Fellowship - UCSF - Katherine Possin, PhD - Early Markers and Brain Bases of Spatial Impairment in Alpha-synuclein Disorders |
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Fellowship - UC Irvine - Carrie Peltz, PhD - The Examination of Cognitively Impaired but Not Demented Oldest-Old |
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Start-Up - UCLA - Zhefeng Guo, PhD - Solid-supported EPR: A Novel Approach to Study Beta-Amyloid Structures |
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Start-Up - UCSD - Subhojit Roy, MD, PhD - Axonal Transport Deficits and Therapeutic Avenues in Alzheimer’s Disease |
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Center - UCSF - Cynthia Kenyon, PhD - Larry L. Hillblom Center for the Biology of Aging |
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Fellowship - UCSF - Daniel Hesselson, PhD - Regulation of Pancreatic Morphogenesis in Zebrafish |
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Fellowship - UC Irvine - Pablo Helguera, PhD - Molecular Mechanisms Associated with Type 2 Diabetes in Down's Syndrome |
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Fellowship - UCSF - Rachel Friedman, PhD - Interplay of T cells and APCs in Type I Diabetes Onset and Maintainence |
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Fellowship - UCSD - Ji Zhang, MD, PhD - Beyond Insulin Secretion: The Role of Mitochondrial Phosphatase PTPMT1 in Diabetes |
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Network - UCLA - Peter C. Butler, MD - Larry L. Hillblom Islet Research Center Network Grant |
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Fellowship - Stanford University - Yelena Budovskaya, PhD - Transcriptional Circuit for Aging in C.elegans |
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Fellowship - UCSF - Geoffrey Kerchner, MD, PhD - Shuffling AMPA Receptors: TARPs and Synaptic Plasticity |
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Fellowship - UCSF - Hong Xu, PhD - Genetic Dissection of Mitochondrial Calcium Signaling in Neurodegeneration |
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Fellowship - The Gladstone Institute - Jing-Yi Huang, PhD - Regulation of GST Protein Function by Reversible Acetylation: Role of SIRT3 |
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Fellowship - UCSF - John Price, PhD - A Mechanistic Study of Infectious Proteins |
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Fellowship - UCSF - Huidy Shu, MD, PhD - Analysis of Frontotemporal Dementia Genes in Drosophila |
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Fellowship - UCSF - Quasar Padiath, PhD - Elucidating of the Mechanism of Lamin B1 Dependent Adult Onset Demyelination |
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Fellowship - The Gladstone Institute - Gaia Skibinski, PhD - Investigating Mutant LRRK2 Toxicity in an In Vitro Neuronal Model |
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Fellowship - UCSF - Della David, PhD - The Role of Protein Aggregation in Normal Aging and Neurodegeneration |
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Start-Up - Stanford University - Isabella Graef, MD - Borrowing Endogenous Protein Surfaces to Inhibit Pathogenic Protein Interactions |
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Start-Up - UCSF - Yuriy Kirichok, PhD - Molecular Mechanisms Governing Mitochondrial Calcium Uptake |
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Start-Up - UCSF - Victor Valcour, MD - Cognitive Health and Brain Vulnerability in Aging Insulin Resistant Patients |
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Start-Up - UCSF - Doug Gould, PhD - Determining Allelic Differences and Cellular Mechanisms in a Novel Model of AMD |
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Network - UCSF - Stanley Prusiner, MD - Diagnosis and Treatment of Age-Dependent Neurodegeneration |
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Network - UCSD - Laura L. Dugan, MD - Mapping the Redox Biology of Aging |
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Network - UCSB - Kenneth Kosik, MD - The Pathobiology of Tau Inclusions |
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Start-Up - The Buck Institute - Xianmin Zeng, PhD - The roles of Nurr1 and Pitx3 in dopaminergic differentiation of hESC |
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Fellowship - Stanford University - Xiao Liu, PhD - Analysis of gene expression of aging in C. elegans |
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Fellowship - The Gladstone Institute - Vicente Sancenon, PhD - High-throughput screens in yeast to identify therapies for Parkinson’s disease |
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Network - UCLA - S. Thomas Carmichael, MD, PhD - The Larry L. Hillblom Foundation Network for Neural Repair After Str |
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Network - UCSF - Bruce Miller, MD - A Hillblom Network Program for the Pre-Clinical Identification of Dementia |
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Network - UCSD - William Mobley, MD, PhD - Exploring The Link Between Increased APP And Neurodegeneration in Down Syndrome |
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Network - UC Irvine - Charles G. Glabe, PhD - Interaction of amyloid oligomers with membranes: pathogenesis and therapeutics. |
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Network - The Buck Institute - Gordon J. Lithgow, PhD - Chemical Biology of Aging |
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Fellowship - UCLA - Yoshifumi Saisho, MD - Mechanism of ß-cell death in Type 2 Diabetes |
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Start-Up - UCSF - Feroz Papa, MD, PhD - Endoplasmic Reticulum Stress and Type 2 Diabetes |
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Network - UCSF - Michael German, MD - The Larry Hillblom Islet Genesis Network |
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Network - The Whittier Institute - Alberto Hayek, MD - Mechanisms of Pancreas Development |
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Fellowship - Stanford University - Ke Zhan, PhD - Pathogenetic Mechanisms in Down Syndrome and Alzheimer's Disease |
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Fellowship - UCSF - Ken Nakamura, MD, PhD - The Real Time Analysis of Synuclein Multimers in Live Cells |
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Start-Up - UCSF - William W. Seeley, MD - Anterior Cingulate, Insular and Frontoinsular Vulnerability in FTLD and AD |
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Start-Up - UCLA - Linda Ercoli, PhD - Plaque and Tangle PET Imaging in Mild Cognitive Impairment |
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Fellowship - Stanford University - Serge Dumoulin, PhD - Cortical Plasticity and Reading in Age-Related Macular Degeneration |
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Fellowship - The Scripps Institute - Hong Hua, PhD - Function of BMP4 and Id Proteins in the Expansion of Pancreatic Progenitors |
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Fellowship - The Buck Institute - David Madden, PhD - Mechanism of Endoplasmic Reticulum Stress-induced Cell Death |
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Fellowship - UCSF - Aimee Kao, MD, PhD - Alpha-synuclein Expression and Aging in C. elegans |
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Fellowship - UCSF - Peichuan Zhang, PhD - Mechanistic Investigation of Aging and Age-related Neurodegeneration in C. elegans |
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Fellowship - UCSF - Montserrat Arrasate, PhD - Longitudinal Analysis to Study PolyQ-dependent Death Mechanisms in Specific Neuronal Subpopulations |
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Start-Up - UCLA - Leena Haataja, PhD - The Role of Uncoupling Proteins in Glucose-stimulated Insulin Secretion in Diabetes |
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Network - UCLA - Peter C. Butler, MD - Larry L. Hillblom Islet Research Center at the University of California, Los Angeles |
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Building - UCLA - Peter C. Butler, MD - Larry L. Hillblom Islet Research Center |
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Fellowship - UCSD - Magdalena Chechlacz, PhD - The Molecular Basis of Human Mental Retardation |
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Clinical - UCSF - Jonathan C. Horton, MD, PhD - Neural Mechanisms of Strabismus |
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Start-Up - UCSF - Steven P. Miller, MD.CM.FRCP(C) - Brain Injury and Development in Newborns with Congenital Heart Disease |
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Network - Stanford University - William Mobley, MD, PhD - Synaptic Structure and Function in Down Syndrome |
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Clinical Research - UCLA - Bruce Dobkin, MD - Recovery of Walking in Older Persons After Stroke |
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Start-Up - UCSF - Katherine Rankin, PhD - Neuroanatomy of Behavior Changes in Dementia |
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Network - UCSF - Bruce Miller, MD - A Hillblom Network Program for the Pre-Clinical Identification of Alzheimer's Disease and Other Age-Related Dementias |
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Start-Up - The Whittier Institute - Charles King, PhD - Proteomics and Endocrine Progenitor Cells |
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Fellowship - UCLA - Linda Ercoli, PhD - A Comprehensive Biomedical Model for Early Detection of Alzheimer's Disease |
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Network - UC Irvine - Charles Glabe, PhD - Interaction of Amyloid Aß and a-synuclein with Membranes - Implications for their Pathogenesis in Alzheimer's and Pa... |
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Fellowship - UCSD - Bjorn Tyrberg, Dr Med Sc - T-cadherin in the Pancreas: Role in Islet Development, Regeneration and the Pathogenesis of Type 2 Diabetes |
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Start-Up - USC - Anil Bhushan, PhD - Proliferation and Differentiation of Pancreatic Progenitor Cells |
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Network - UCSD - Alberto Hayek, MD - Diabetes Mellitus - Induction of Insulin Biosynthesis and Release from Endocrine Progenitor Cells |
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Network - The Salk Institute - Inder Verma, PhD - The Larry L. Hillblom Center for Diabetes |